How confident can we be that orthologs are similar, but paralogs differ?
نویسندگان
چکیده
منابع مشابه
How confident can we be that orthologs are similar, but paralogs differ?
Homologous genes are classified into orthologs and paralogs, depending on whether they arose by speciation or duplication. It is widely assumed that orthologs share similar functions, whereas paralogs are expected to diverge more from each other. But does this assumption hold up on further examination? We present evidence that orthologs and paralogs are not so different in either their evolutio...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2009
ISSN: 0168-9525
DOI: 10.1016/j.tig.2009.03.004